They affect the heart, nervous system, and musculoskeletal system as well. They also contribute to the development of bacterial flora and enzyme system in the intestine.
Glucocorticoids also help in the development of the hepatic enzyme system during fetal life, surfactant synthesis in the fetal lung, and maturation of lungs during intrauterine life. They are important for the development of the mammary gland during puberty in females. They act as vasopressors and bronchodilator effects of catecholamine, calorigenic effects of glucagon and catecholamines, and lipolytic effects of catecholamine. Glucocorticoids are essential for some physiological actions of other hormones. P392 READE, B., and MORGAN, A.F.: Relationship of riboflavin deficiency to adrenocortical function as shown by carbohydrate metabolism in anoxia. 17-hydroxypregnenolone then moves into the endoplasmic reticulum and is converted into 17 hydroxyprogesterone. READE B MORGAN A.F Relationship of riboflavin deficiency to adrenocortical function as shown by carbohydrate metabolism in anoxia. In the mitochondria, pregnenolone forms 17-hydroxypregnenolone by the enzyme 17 alpha-hydroxylase. The main glucocorticoid formed are cortisol and corticosterone. Zona reticularis also contributes to this. The synthesis of glucocorticoids occurs mainly in the zona fasciculata of the adrenal cortex.
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